About Dr. Mario Castillo-Sang,
Heart Valve Surgeon

Hello! My name is Dr. Mario Castillo-Sang and I am a cardiac surgeon having graduated from Escuela de Medicina Ignacio A Santos in 2004. St. Elizabeth Healthcare performs approximately 600 heart surgeries each year. All St. Elizabeth Healthcare cardiac surgeons complete between 125-150 cardiac cases per year. Read more...

39 Patient Reviews for
Dr. Castillo-Sang

"Dr. Mario Castillo-Sang was excellent. The nurses were very helpful and my recovery has been better than I expected. My surgery was on Monday and I was home by noon on Thursday. Now, at 10 days after surgery, I have no pain and feel almost back to normal."

-- Don Combs, Mitral Valve, Valve Repair, 10/13/2025

"He was my savior. He’s excellent. He saved my life."

-- Linda Amon, Mitral Valve, Valve Replacement, 09/10/2025

> See 37 more patient testimonials

My Specialities &
Clinical Interests

My heart surgery specialties include:

  • Minimally invasive mitral valve surgery using endoscopic techniques
  • Atrial fibrillation (Maze procedure)
  • Transcatheter valve therapy including TAVR

In addition, I have research and clinical interests specific to:

  • Ventricular contractility in Barlow's mitral valve disease and in bileaflet prolapse
  • Coronary revascularization
  • Mitral valve imaging

Education, Training & Certificates

Dr. Mario Castillo-Sang, heart surgeon, graduated from Escuela de Medicina Ignacio A Santos in 2004.

After medical school, Dr. Castillo-Sang completed a general surgery residency at University of Toledo College of Medicine in 2010. Next, he completed a cardiothoracic surgery fellowship at Washington University Barnes Jewish Hospital in 2012.

Dr. Castillo-Sang is a nationally-recognized heart valve expert that practices in Kentucky. He specializes in minimally-invasive mitral valve repair surgery using endoscopic techniques.

Dr. Castillo-Sang is board certified by the American Board of Thoracic Surgery. Dr. Castillo-Sang has earned a spot on Cincinnati Magazine's "Top Doctors".

Schedule Appointment
with Dr. Mario Castillo-Sang, MD

To schedule an appointment with Dr. Castillo-Sang, you can:

The office of Dr. Castillo-Sang is located at 711 Medical Village Drive, Suite 310, Edgewood, KY 41017. To get driving directions to this office, please click the map below.



> Click for driving directions to Dr. Castillo-Sang’s office.

Watch Educational Video with Dr. Mario Castillo-Sang

Learn about heart valve surgery from Dr. Castillo-Sang in this video:

  • Endoscopic Cardiac Surgeons Club: What Should Patients Know?

Page last updated: October 23, 2025