Dr. Mario Castillo-Sang, heart surgeon

Dr. Mario Castillo-Sang

St. Elizabeth Healthcare - Edgewood
711 Medical Village Drive, Suite 310, Edgewood, KY 41017
(‍859) 495-3320

About Dr. Mario Castillo-Sang,
Heart Surgeon

Hello! My name is Dr. Mario Castillo-Sang and I am a cardiac surgeon having graduated from Escuela de Medicina Ignacio A Santos in 2004. St. Elizabeth Healthcare performs approximately 600 heart surgeries each year. All St. Elizabeth Healthcare cardiac surgeons complete between 125-150 cardiac cases per year. Read more...

83 Patient Reviews for
Dr. Castillo-Sang

"Dr. Castillo-Sang has been wonderful from the first time we met him. He is a wonderful teacher, educator as well as very personable and obviously a skilled surgeon.
He was highly recommended by more than one source outside of the St. Elizabeth Healthcare system and has met every expectation."

-- Rosemarie Anderson, Mitral Valve and Valve Replacement, 06/01/2026

"This surgeon is amazing, No pain after surgery. I am impressed with his bedside manner and the way he treats his patients. I would recommend him to anyone."

-- John Turner, Mitral Valve and Valve Replacement, 05/19/2026

My Specialities &
Clinical Interests

My heart surgery specialties include:

  • Minimally invasive mitral valve surgery using endoscopic techniques
  • Atrial fibrillation (Maze procedure)
  • Transcatheter valve therapy including TAVR

In addition, I have research and clinical interests specific to:

  • Ventricular contractility in Barlow's mitral valve disease and in bileaflet prolapse
  • Coronary revascularization
  • Mitral valve imaging

Education, Training & Certificates

Dr. Mario Castillo-Sang, heart surgeon, graduated from Escuela de Medicina Ignacio A Santos in 2004.

After medical school, Dr. Castillo-Sang completed a general surgery residency at University of Toledo College of Medicine in 2010. Next, he completed a cardiothoracic surgery fellowship at Washington University Barnes Jewish Hospital in 2012.

Dr. Castillo-Sang is a nationally-recognized heart valve expert that practices in Kentucky. He specializes in minimally-invasive mitral valve repair surgery using endoscopic techniques.

Dr. Castillo-Sang is board certified by the American Board of Thoracic Surgery. Dr. Castillo-Sang has earned a spot on Cincinnati Magazine's "Top Doctors".

Schedule Appointment with Dr. Mario Castillo-Sang, MD

To schedule an appointment with Dr. Castillo-Sang, you can:

The office of Dr. Castillo-Sang is located at 711 Medical Village Drive, Suite 310, Edgewood, Kentucky 41017. To get driving directions to this office, please click the map below.

Watch Educational Videos with Dr. Mario Castillo-Sang

Learn about heart valve surgery from Dr. Castillo-Sang in these videos:
  • Endoscopic Cardiac Surgeons Club: What Should Patients Know?
  • Inside Access: Endoscopic Training Lab
Page last updated: June 9, 2026